ラットにおけるファロペネムナトリウムとバルプロ酸ナトリウム同時投与における血漿中バルプロ酸濃度

抄録

The drug interaction between sodium valproate (VPA), an anticonvulsant, and faropenem sodium (FRPM), a new penem antibiotic drug, was studied in rats. No significant change was observed in the plasma VPA concentration when compared with the control after the administration of VPA (TOO mg/kg per oral) simultaneously with FRPM (600 mg/kg per oral).