病院薬学
Online ISSN : 2185-9477
Print ISSN : 0389-9098
ISSN-L : 0389-9098
ビタミンK1, K2注射剤の保存中および混合輸液中での光分解
山路 昭藤井 康子奥田 陽子青野 真知子佐藤 健太郎千葉 幹夫平岡 栄一
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1978 年 4 巻 1 号 p. 7-11

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Photodegradation of vitamin K1 and K2 injections during preservation and in intravenous admixtures was investigated by high-pressure liquid chromatography. When exposed to fluorescent light (500 lux), 50% of commercial product (10mg) of vitamin K1 decomposed in about 15 days, compared with about 10 days for the 50% decomposition of vitamin K2 product. In the intravenous admixtures for drip infusion, the residual rate after sunlight irradiation (2, 000 lux) for 3 hours was 43-63% for K1 and 31-44% for K2. Therefore, intravenous admixtures containing theselight-unstable injections require shading during drip infusion. In Osaka University Hospital, the light-resistant covers of containers for injections are used for this purpose.

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