抄録
Physical and chemical stability of suppositories containing aminophylline and various bases prepared in our hospital pharmacy was investigated. It was found that ethylenediamine in aminophylline was decreased, melting point of suppositories rose and disintegration and liquefaction time was delayed in suppositories with Witepsol base when stored at room temperature.
Thin-layer chromatography produced evidences supporting that ethylenediamine may react with some Witepsol constituents to form acid amide linkage. However, the suppositories were stable at lower temperature. Suppositories prepared with PEG base were found to be satisfactorily stable at room temperature.
