抄録
The quality of 8 commercially available pantethine products of powders, fine granules or granules was evaluated by several tests on pharmaceutical properties such as stability. 50% dissolution time (T50) of each product was less than 5 min and no difference in T50 was observed among the products. Content of 6 products was lower than the labeled amount, and most of these products showed some impurities detected on TLC. 6 products were unstable under severe conditions of high temperature and humidity. 7 products showed adhesive property, uhile 2 products showed a large content segregation of different-size fractions.
It was found that the products containing same ingredient show qualitative difference due to the difference in production technique.
