抄録
Recombinant human granulocyte-colony stimulating factor (rhG-CSF) is administered either by intravenous drip infusion or subcutaneous injection depending on the indications. In the case of intravenous drip infusion, adsorption of rhG-CSF to the extension tube and infusion bottle can have an impact on clinical efficacy, since rhG-CSF is given at very small doses. In the present study, we attempted to determine the degree of adsorption of rhG-CSF [GranM300 (M300), Gran300 (G300), Gran150 (G150)] to extension tubes. The recovery rate of rhG-CSF changed a little with quality of the materials of the extension tube. In M300, when the length of a tube was 2 m and 4 m, the recovery rate of rhG-CSF was 89.4-91.0%, 82.6-89.1%, respectively. In G300, the recovery rate of rhG-CSF was 92.6-96.6%, 87.2-96.6%, respectively. In G150, the recovery rate of rhGCSF was 80.2-88.0%, 76.6-79.1%, respectively. From these results, it was suggested that the longer the tube, the greater the rate of adsorption. Moreover, the lower the concentration rate, the higher the rate of adsorption.
