抄録
1. The reduction in the plasma K of K-deficient rats was in proportion to days of feeding of K-free diet, while no significant change was recognized in the plasma Na level.
2. A decrease in muscle K was not compensated by an equivalent increase in muscle Na during the first 5 weeks of K-deficiency, but the ratio of the number of Na ions entering the muscle to that of K ions coming out during further K-deficiency became approximately 1: 1. The net movement of ionic composition in SOLs was greater than that in EDLs.
3.[Na] i and [K] i in chronically and acutely denervated SOLs of K-deficient rats were modified close to a normal value as compared with innervated companions, but recovery of the ionic concentration by denervation was not found in denervated EDLs. Simultaneously, facilitation of the active movement of Na and K ions in denervated SOLs was observed in K-deficient rats which received 1.5mM/Kg. of K-salts for a week as well as 6mM/Kg. of Na-salt for 3 days after denervation.
4. The treatment of K-deficient rats with normal diet for a week as well as 6mM/Kg. of K-salts for 3 days resulted in marked restoration of the ionic composition in plasma and muscles, the active movement of Na and K ions in innervated muscles being greater than that in denervated ones. Furthermore, inhibition of the active transport was greater in denervated EDLs than in denervated SOLs.
5. Active K uptake was quantitatively greater than Na excretion in both kinds of SOLs and innervated EDLs when K-deficient rats received 1.5mM/ Kg. of K-salts for a week. On the other hand, the rate of recovery of K uptake to Na excretion of K-deficient rats which were fed a normal diet for a week or received 6mM/Kg. of K-salts for 3 days was 1: 1.
6. The wet weight of denervated muscles was smaller than that of innervated ones when both SOL and EDL muscles were weighed at the end of the experiments.
