抄録
1. The effects of stimulation of the peripheral ends of the splanchnic nerve have been studied in isolated toad liver.
2. An increase in glucose concentration in perfusate in response to splanchnic nerve stimulation as well as adrenaline or noradrenaline application was observed.
3. Relationship between stimulus frequency and release of glucose was studied. From the experiments it was found that the amount of glucose released from the liver is closely related to the number of electrical pulses applied to the nerve.
4. Perfusate accumulated during splanchnic nerve stimulation in an isolated liver preparation showed a vasoconstrictor effect on blood vessels in the rabbit ear. Perfusate accumulated from reserpinized toad liver showed no vasoconstrictor effect.
5. Reserpine blocked the effect of nerve stimulation on release of glucose but not that of adrenaline application. Propranolol blocked the effect of stimulation as well as that of adrenaline injection. Dibenamine showed no blocking effect.
6. It is concluded that without vagal influence the release of glucose occurs in the liver as the result of splanchnic nerve stimulation via the hepatic innervation in toad.
