抄録
The participation of the heart in shock syndrome formation during endotoxin shock is a problem still awaiting solution. The task undertaken is to assess the work of the left ventricle and arterial pressure in rabbits before and after endotoxin injection at a dose of 2mg•kg-1. Heart rate is the first to reach significantly lower values-at 30min (p<0.05). At 45min, there are significant reductions in dP/dtmax (p<0.01), (dp/dt)/P40 (p<0.001), LVP (p<0, 05), and increase in dP/dtneg (p<0.02). Both the systolic and diastolic blood pressures were significantly decreased at 60min. The data obtained warrant the assumption that impaired myocardial contractility plays a part in the formation of shock syndrome in rabbits exposed to endotoxin.
