We report a case of cutaneous nocardiosis in a 75-year-old man who had previously injured his right lower limb in a bike accident nine years and again six years prior. Over the previous month, the condition of the injury had worsened, causing debilitating pain and prompting the patient to seek medical attention. Cultures and pathological tissues from small cysts and granulation tissue revealed no malignant findings. Consequently, surgical debridement and antibiotic treatment were initiated. Initially, a broad-spectrum antibiotic regimen (TAZ/PIPC and DAP) was administered due to the non-specific nature of the infection. However, subsequent identification of Nocardia species led to modification of the antibiotic regimen to MINO and ST. Following debridement, the patient experienced pain reduction, regained the ability to walk, and was discharged from the hospital. Oral antibiotics were continued post-discharge, and no recurrence of the disease was observed.
