Amputation is often the treatment of choice for wounds that expose the joint cavity. A 46-year-old man was admitted to the hospital in poor general condition following coronavirus infection. The patient had developed bilateral knee joint ulcers caused by pressure sores. Skin ulcers that exposed the joint space were observed at the knee joints. Bacterial cultures were negative; however, the patient underwent negative-pressure wound therapy with continuous irrigation (NPWTci) in case of culture-negative infection. The patient's lower extremities were salvaged and the patient could walk using a walker. NPWTci and flap reconstruction are effective treatments for patients with persistent knee ulcers.
