This study investigated the long-term biological effects of the Excimer Laser. The surface of the skin and buccal mucosa in the rat were irradiated with a KrF Excimer Laser at a wave length of 248nm (skin for 15 seconds; buccal mucosa for 2 seconds) at a pulse repetition rate of 20Hz and a pulse width of 15nsec. The peak power was 6MW and average power was 1.8W; spot size was 4.0×1.0mm.
The irradiated skin tissue and buccal mucosa, heart, lung, kidney, liver, and spleen were removed two years after irradiation and stained with H-E stain for pathological examina tion.
KrF Excimer Laser irradiation at 248nm did not cause carcinogenesis and there were noremarkable observations in the skin, buccal mucosa, or other organs (heart, lung, kidney, liver, and spleen), except for two benign tumors one arising from the alar part and the other from the axillary region.
