抄録
To make assessment of ventilation-perfusion unevenness on anesthetized dog, two compartmental analysis was performed by the equilibration technique using three tracer gases.
Anesthetized mechanically ventilated dogs breathed the mixutre of methane, ethane, nitrous oxide and oxygen for about 30 to 40 minutes on supine position.
While breathing the gas mixture, samples of expired gas, arterial and mixed venous blood were simultaneously collected, and analysed with a gas chromatograph in terms of three tracer gases.
On each tracer gas a mixing equation for the expired gas, a mixing equation for the arterial blood, and two equilibrium equations were established. Since three tracer gases were used in the experiment, twelve equations composed a set of equation complex, in which twelve unknowns were involved.
With this equation complex here represented were the lung compartments accompanied by the ventilation-perfusion ratio of 0.16±0.02 and 0.99±0.10.
Comparing with the “washout technique”, advantage of this method existed in easier analytical procedure to provide one with much accurate information. Disadvantage of this method was that one has to use three tracer gases for the two compartmental analysis.
