化学療法剤の胸腔内投与に関する研究

Cephalosporin 類について

抄録

Chemotherapeutic agents are customarily given intrathoracically to patients with pleurisy, pyothorax, spontaneous pneumothorax or thoractomy for the treatment and prophylaxis of infections. The fate of these drugs after intrathoracic administration, however, is not fully understood. In this study, the serum levels and urinary excretion of five kinds of cephalosporins were compared in healthy rabbits after intrathoracic administration (I. T.) of single doses (20mg/kg). Peak serum concentrations of cefazolin, cephalothin, cephaloridine, ceftezole and cephapirin were respectively 1/3, 3/4, 1/3, 1/6 and 1/2 of peak serum levels after intramuscular administration (I. M.). There were considerable differences in absorption from the thoracic cavity among the cephalosporins tested. However, the serum levels after I. T. persisted longer than those after I. M.. This tendency was also seen in patients.