抄録
Asthma is a clinical syndrome manifested by reversible and intermittent obstruction of the bronchi. The reported incidence of aspirin-induced asthma varies from 2.3 to 20.0%, and causes the highest incidence of all drug-induced asthma. Nevertheless the etiology of aspirin-induced asthma is unknown.
The present investigation was conducted to explore the effects of aspirin on the contraction of guinea-pig tracheal tissues with various bronchoconstrictors. Male guinea-pigs, weighing 250-300g, were killed. Guinea-pig tracheal tissues were removed and suspended in a bioassay glass jackets and superfused with Krebs-Hensleit solution at 37°C, saturated with oxygen and carbon dioxide (95:5, v/v). Contraction of tissues was detected by an isotonic transducer and displayed on a polyrecorder.
1) The contractile responses of guinea-pig tracheal tissues with acetylcholine were markedly increased with continuous infusion of aspirin and were dose related.
2) The contractile responses of guinea-pig tracheal tissues with histamine, serotonin, prostaglandin F2α and bradykinin were increased with continuous infusion of aspirin and became bigger by increasing the dose of aspirin.
3) These results suggest that aspirin lowers the threshold of various bronchoconstrictors, and that such a mechanism may play a very important role in the pathophysiological aspects of aspirin-induced asthma.
