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1. Pneumonia as an opportunistic infection
Pneumonia caused by gram negative bacilli (GNB) which belong to Enterobacteriaceae is found increasingly in recent years. It occurs in most cases nosocomially in patients with severe diseases such as malignant tumor, malignat lymphoma, leukemia, etc. and treated with anticancer drugs, immunosuppressive substances, radiation, adrnocortical steroids etc.
Pneumonia caused by Pneumocystis carinii is also an opportunistic infections and occurs in patients treated with long-term, large dose steroids, immunosuppressive substances etc. for leukemia, malignant lymphoma, organ implantation etc.
The causative protozoa, Pneumocystis carinii can be found by Gomori's methonamine silver stain in needle-puncture fluid and in needle- or pen biopsied specimen.
Intramuscular or intravenous injection of pentamidine isothianate 4mg/kg/day for one to two weeks is effective in nearly the half of the cases.
2. Causative bacteria in pneumonia
From a few reports in recent years it can be inferred that the causative bacteria in primary simple pneumonia (pneumonia in patients without severe complications) is still Str. pneumoniae or Hemophilus influenzae and both of them have few resistant strains against common antibiotics.
3. Causative bacteria in broncho-pulmonary infections
The endeavour to find out or to determine the causative bacteria in pneumonia by many authors was tabulated and our method, the so-called Washculture method of sputum was introduced.
4. Experimental model for the study of pharmacokinetics of antibiotics
The pharmacokinetics of antibiotisc in diseased organ tissue must be different from that of experimental healthy in these rabbit lung were introuduced and discussed.
