抄録
Heparin and dextran sulfate (D. S) are known to accelerate fibrinolytic activity and the recent increasing evidence of the inhibitory effect of D. S. on fibrosis suggests the possibility of this drug being useful for prevention of radiation fibrosis of the lung. To evaluate this we undertook both clinical and experimental studies and obtained the following results:
1) Pulmonary radiation injuries were less severe in degree and more delayed in onset in D. S. treated cases. Preventive effects of D. S. were most prominent in small radiation fields. There was no significant difference among the various radiation doses.
2) Experimentally, pulmonary radiation injuries were observed in 94% of X-irradiated mice. (unilateral lung field, 3000R, once a week, 3 weeks). Histological evaluation revealed no significant difference in pulmonary injury between the D. S.-treated group and control.
