肺の好酸球性肉芽腫の一生検例について

抄録

A biopsy case of eosinophilic granuloma of the lung was studied by light and electron microscopy with special reference to so-called ‘histocytic cells’.
The patient was a 29 year-old man with a chief complaint of dry cough for the last ten months and who showed clubbing fingers and diffuse reticular shadow on his chest X-ray film.
The specimen obtained on thoracotomy revealed multiple granulomatous lesions growing in the peribronchiolar and peripheral air way walls. They consisted of large histiocytic cells with various degree of eosinophilic infiltration and fibrous connective tissue.
Electronmicroscopically, the histiocytic cell characterized with so-called Langerhans cell granules contained well developed Golgi apparatus with attended lysosomal cytosomes without pagolysosomal structures and somewhat developed r-ERs tending to dilate and contain a flocculated material, as far as ones seen in an active fibroblast. Furthermore, it was noted that collagenous bundles with microfibrils were intimately related to the cell membrane of Histiocytic cells without close relationship to ordinary fibroblast.
Histiocytic cells of EG of the lung might be of a special state of a mesenchymal cell different from an ordinary- described histiocytes and might participate in fibrogenesis.