抄録
Lung functions of 50 patients with sarcoidosis (stage O; 11, stage I; 33, stage II; 6, ) were studied. All cases were considered to be mild because of their clinical findings.
The results were obtained as follows:
1) Abnormalities of DLco and Pao2 were significantly frequent in stage II.
2) Small airway dysfunction was frequently detected in the cases, also in non smokers. However, decrease in VC and Cst was not observed, and decrease in DLco was found in only 4 cases (8%). Therefore, small airway dysfunction may be the most characteristic finding in mild cases of sarcoidosis.
3) Small airway dysfunction was suggested to be mainly due to increase in resistance of airways narrowed by sarcoid granuloma or peribronchial fibrosis. The loss of elastic recoil at 60% TLC was observed in only one case, so it might not be a main factor of small airway dysfunction.
