気管支・気管支血管系間の局所的メカニズムについて

抄録

To study the inter-relationships between the bronchial muscular activity and bronchial vasomotor tone, the changes in airway and in bronchial arterial system to the administration of isoproterenol, isoxsuprine, aminophylline and angiotensin into bronchial artery, and to the injection of serotonin and histamine into the pulmonary artery were tested simultaneously in the anesthetized and thoracotomized dogs.
The administration of isoproterenol, isoxsuprine and aminophylline into bronchial artery resulted in the dilatation of airway and of bronchial vasculature, while the administration of angiotensin resulted in the constriction of both systems. Since the results were different from the previous findings, where the reverse relationship were observed in the changes of both systems following the injection of serotonin, histamine, acetylcholine and 1-epinephrine into bronchial artery, the different mechanism might be suspected that these agents acted directly on the smooth muscle of airway and of bronchial artery.
The administration of serotonin and histamine into pulmonary artery in the preparation where the bronchial artery was separated from the systemic circulation, also produced the dilatation of bronchial vasculature. No marked changes were observed following the section of vagi and thoracic sympathetic nerves.
From these results it was concluded that there is an intrinsic mechanism between airway and bronchial artery such as increased bronchial muscular activity may result in a secondary bronchial vasodilatation.