抄録
Abnormalities of sex chromatin bodies such as multiplication or disappearance in cancerization have ever been reported. The present paper is to confirm the evidence and to investigate the entity of the abnormalities.
For demonstration of sex chromatins, 0.1% thionin buffered solution (pH 5.7) after 1N HCL treatment was used.
The positve rate of sex chromatin positive nuclei was 25.1±6.4% in normal cases, 22.7±4.7% in Dysplasia low degree, 18.1±4.5% in Dysplasia high degree, 15.9±6.1% in carcinoma in situ and 11.3±4.5% in invasive carcinoma. Although double or triple sex chromatins appeared in abnormal cells (1 to 2%). The incidence of double sex chromatin was 0% in normal cases, 2.7% in dysplasia, 12.2% in carcinoma in situ and 16.2% in invasive carcinoma.
There was no relation between sex chromatin size and nuclear size, but a significant interrelation between the sex chromatin size and DNA content in normal cases.
