Adenosquamous carcinoma in situ (AIS +CIS) of the uterine cervix is a rare lesion. However, the lesion may be overlooked due to the well-established cytologic findings of CIS component, whereas AIS has not been studied thoroughly.
The cyto- and histo-pathologies of our case have been described in comparison with those in the literature cases. Our cytologic observations include clusterizations of cells with occasional acinous or palisading arrangement, abundant lacy or vacuolized cytoplasm with pleomorphism and a small but marked nucleolus in a fine granular nucleus. When these findings are observed in addition to typical CIS cells, the possibility of AIS +CIS should be estimated.
Literature review is also made concerning the incidence, relation to pregnancy, opinions for diagnostic criteria and the histogenesis of the tumor.
