日本臨床細胞学会雑誌
Online ISSN : 1882-7233
Print ISSN : 0387-1193
ISSN-L : 0387-1193
腹水に異型細胞が出現した横紋筋肉腫の1症例
横紋筋肉腫細胞の免疫学的および電顕的同定
富野 康日己伊藤 哲夫小林 克己小黒 義次広野 秋男
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1978 年 17 巻 3 号 p. 370-373

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A reliable histological feature of rhabdomyosarcoma is the cross-striation of myofibrills in the cytoplasm of tumor cells. Though the patients with rhabdomyosarcoma develope rarely the fluid accumulation in the abdominal cavity, the identification of origin of tumor cells found in the ascites is difficult.
The patient was a 26-year-old female, from whom rhabdomyosarcoma of the left foot had been excised, the tumor cells appeared in the ascites were identified as rhabdomyosarcoma cells by means of immunopathological method. The tumor cells from ascites were treated with allogeneic anti-skeletal muscle serum obtained from the patient with myasthenia gravis and then reacted with rabbitanti-human immunoglobulin serum labeled with FITC.
Clusters of granular specific immunofluorescence were observed in the cytoplasm of tumor cells. The site of specific immunofluorescence was coincide with the location of myofibrills in the cytoplasm observed by electron microscopy.
The immunopathological method employed might be adjunctive importance for the determination of Origin of tumor cells existing in the.fluid of abdominal or thoracic cavity.

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