Both cervical scraping with the spatula and the cotton applicater can be considered as valuable methods in screening for cervical neoplasia. An attempt to compare the spatula with cotton applicater for usefullness to detect not only the presence of cervical neoplasia but also to prognosticate its severity was made. Furthermore, cellular changes after application of acetic acid and the effect of repeated sampling on cellular features were investigated.
The following results were obtained.
1) The positive detectable ratio by the screening with the spatula was 83.9% in dysplasia and 100% in carcinoma in situ (CIS), on the other hand, 54.8% of dysplasia and 71% of CIS were detected by the screening with the cotton applicater.
2) The accuracy of cytology with the spatula was 87.0% in CIS, 84.1% in microinvasive cancer and 97.0% in frank invasive cancer, with cotton applicater was respectively 41.7%, 40.0%, 84.4%. Thus, recognition of CIS, microinvasive cancer and frank invasive-cancer with the spatula can be made in a high proportion of cases.
3) The cellular features after application of acetic acid had a tendency to over diagnosis.
4) Three weeks'interval was needed the restration for the cellular sampling.
