Follow up study of the cervical human papillomavirus infections in the women with vulval condylomata acuminata

Abstract

Twenty-five women suffering from cervical human papillomavirus (HPV) infection with vulval condylomata acuminata were followed up by cytological examination for over one year to establish the biological potential of HPV.
Seventy-six %(18/25) of the patients were between 10 and 20 years old. In the nonpregnant group, the incidence of koilocytosis on the cytological examination was 33% the first time, 16% after 3 month, 11% after 6 month, and 11% after 1 year. However, the respective incidences including dyskeratosis and binucleation with koilocytosis were 77%, 71%, 61% and 22%. Furthermore the results of follow up by colposcopy and histologic examination after 1 year were as follows: 6% slightly progressed, 33% persistent, 39% regressed and 22% disappeared. Condylomatous cells did not always appear during follow up cytologic examinations except in the patients with immunosuppressive condition, but colposcopic findings were usually observed. In the pregnant group (7 cases), cases with slight progression accounted for 39% of the total.
The results suggested that the cervical lesions estimated as HPV 6/11 tended to regress and disappear after 1 to 1.5 years. However, HPV 16 was sometimes associated with cervical lesions of HPV infection. Therefore, persistent cases should be followed up over the long term by HPV DNA typing.