An immunocytochemical study of NCC-ST-439 in gynecology

Abstract

We studied clinical and cytological significance of NCC-ST-439 in gynecology. It was a new monoclonal antibody which recognized tumor associated antigen. We examined the location of its corresponding antigen in tumor and normal cells using immunocytochemical method.
NCC-ST-439 antigen showed positive in the cases of cervical carcinoma (3/11 cases, 27%) endometrial carcinoma (6/11 cases, 55%) and ovarian carcinoma (6/11 cases, 55%). But it was negative in cells of normal cervical epithelium, endometrial gland, villi and decidua.
It was suggested that NCC-ST-439 was interesting and useful tumor marker, which had low false positive ratio, in gynecological cytology.