Correlation between CIN and human papilloma virus infection

Abstract

Correlation between CIN (cervical intraepithelial neoplasia) and HPV (human papilloma virus) infection was studied by cytology, histopathology and filter DNA hybridization.
1) HPV genome was detected in 66.7%(6/9) of condylomata acuminata, in 30.8%(4/13) of mild dysplasia, in 75%(3/4) of moderate dysplasia, in 50%(2/4) of severe dysplasia and 80%(8/10) in carcinoma in situ, while in 2%(1/50) of normal women.
2) When HPV genome was negative by filter DNA hybridization, there were cytological and histopathological evidences of HPV infection in 44%(4/9) of mild dysplasia and in 50%(1/2) of severe dysplasia. This suggests the possibility of uncertain type of HPV infection.
3) When HPV genome was positive by filter DN hybridization, histopathological evidences of HPV infection were found in mild, moderate and severe dysplasia but was not found in carcinoma in situ.