Abstract
Case: We report a case of large granular lymphocytic leukemia with tumor cells in cerebrospinal fluid (CSF). The tumor cells had abundant pale blue cytoplasm with partial azurophilic granules and small-to medium-sized nucleus with a smooth nuclear margin. The number of cells was not increased, in CSF. It was difficult to distinguish between malignant cells and reactive lymphocytes.
Conclusion: An in situ hybridization kit (Epstein-Barr virus encoded small RNA prode, Dakopatts, Denmark) was used in Papanicolaou-destained CSF smears. EB-RNA was detected in all atypical lymphocytes. The lymphocytes infiltrating cerebrospinal fluid were considered to be tumor cell. EB-RNA was also detected in the liver biopsy specimens of this patient.
