This study aimed to evaluate the efficacy of TBPM-PI in children with refractory otitis media. Sixteen cases of acute otitis media in childhood which were resistant to prior therapy were evaluated. Symptom scores (ear pain, high fever, displeasure) and tympanic membrane scores (rubefaction, swelling, discharge) were evaluated before and after treatment with antimicrobial agents. The cure rate was 87.5%. In addition, TBPM-PI showed favorable antibacterial activities against the isolated pathogens. The results suggest that TBPM-PI is a useful antibiotic in cases of pediatric refractory otitis media.
