Clinicopathological Study of 24 Cases of Pemphigoid

Abstract

Pemphigoid is an autoimmune bullous disease characterized by a subepithelial blister. We report 24 cases of pemphigoid who visited our department from 2007 through 2017. Twenty-one cases were classified as mucous membrane pemphigoid and 3 cases as bullous pemphigoid. They consisted of 5 males and 19 females, 44 to 91 years of age （median: 65.5 years）. Lesions in the oral cavity were most frequently located in the gingiva （19 cases）, followed by the buccal mucosa （7 cases） and the palate （6 cases）. Eighteen of the 24 cases showed only oral manifestations. Treatment with systemic steroid was given to 12 cases, and topical steroid to 12 cases. In 8 of the 12 cases with topical steroid, we co-administered tetracycline, diaminodiphenyl and/or nicotinamide. The lesions of all patients were improved, and we have continued to treat them with attention to relapse. It is considered that a prompt diagnosis should be made and appropriate treatment for pemphigoid, which often shows only oral manifestations, should be provided in cooperation with dermatologists.