Pemphigoid is an autoimmune bullous disease characterized by a subepithelial blister. We report 24 cases of pemphigoid who visited our department from 2007 through 2017. Twenty-one cases were classified as mucous membrane pemphigoid and 3 cases as bullous pemphigoid. They consisted of 5 males and 19 females, 44 to 91 years of age （median: 65.5 years）. Lesions in the oral cavity were most frequently located in the gingiva （19 cases）, followed by the buccal mucosa （7 cases） and the palate （6 cases）. Eighteen of the 24 cases showed only oral manifestations. Treatment with systemic steroid was given to 12 cases, and topical steroid to 12 cases. In 8 of the 12 cases with topical steroid, we co-administered tetracycline, diaminodiphenyl and/or nicotinamide. The lesions of all patients were improved, and we have continued to treat them with attention to relapse. It is considered that a prompt diagnosis should be made and appropriate treatment for pemphigoid, which often shows only oral manifestations, should be provided in cooperation with dermatologists.

View full abstract

A 60-year-old female visited our hospital with pain in the right side of the maxillary alveolus. Seven years before visiting our hospital, she had undergone partial glossectomies and postoperative adjuvant radiotherapy due to squamous cell carcinoma （SCC） of the left margin of the tongue at another hospital. Physical examination at the first presentation revealed tumorous lesions in the right maxilla, left cheek and labial gingiva of the anterior mandible. Biopsies were performed and the pathological diagnoses were SCCs for all biopsies. The patient underwent partial maxillectomy, resection of the buccal tumor, and marginal mandibulectomy simultaneously. The patient died 3 years after the initial treatments because of the uncontrolled primary tumor and lymph node metastases.

View full abstract

We experienced a case of secondary syphilis with inflammation of the oral mucosa. The patient was a 24-year-old woman who was referred to our department with chief complaints of healing failure of stomatitis in the oral cavity. Ulcers were found in the tongue and palate, and findings of angina were observed. Both the qualitative and quantitative values of TPHA and RPR were positive. Biopsy from the palate showed positive immunohistochemical staining with anti Treponema pallidam antibody. Flat condyloma was also recognized and diagnosed as secondary syphilis. Ampicillin was administered and the lesion disappeared. Because syphilis is preceded by oral lesions, early detection is important.

View full abstract

Xanthogranulomatous tissue reaction is an inflammatory change that forms granulomas mainly composed of histiocytes, and xanthogranulomatous sialadenitis is extremely rare. Here we report a case of xanthogranulomatous sialadenitis of the sublingual gland. The patient was a 68-year-old Japanese woman. An elastic slightly hard mass with a diameter of 1cm was palpated under the oral mucosa on the right side of the oral floor. We suspected a diagnosis of sublingual gland tumor and performed excisional biopsy. The histopathological diagnosis was xanthogranulomatous sialadenitis. Currently, 2.5 years have elapsed since the surgery, without recurrence.

View full abstract

Behçet's disease is a chronic inflammatory disorder of unknown origin and intestinal Behçet's disease is a rare phenotype. We herein report a case of Behçet's disease with a long duration that was difficult to diagnose. A 56-year-old woman complained of recurrent oral aphtha, fever, skin eruption and abdominal pain for 10 years without diagnosis. Thereafter, multiple symptoms occurred and Behçet's disease was subsequently diagnosed by endoscopy. To diagnose recurrent oral aphtha, it is important to check the clinical history and systemic symptoms.

View full abstract