喘息に対するSGB療法気管支喘息に対する星状神経節ブロックの効果

呼吸機能, ケミカルメディエータ, 自律神経機能および症状を指標とした解析

抄録

The effects of weekly repeated stellate ganglion block (SGB) on the condition of 11 stable bronchial asthmatics (7 women and 4 men, aged between 40 and 63, mean 53.9) were studied. The 7 parameters adopted for assessment of the effects of SGB were as follows: 1) provisional respiratory function; 2) ventilatory function; 3) ventilatory response to carbon dioxide; 4) serum levels of chemical mediators; 5) state of the autonomic nervous system; 6) number of necessary intravenous injections of aminophylline; 7) patients' subjective assessment of their general condition.
The results of repeated SGB were interpreted as follows: 1) respiratory resistance was decreased; 2) no adverse effects on SpO₂, E_TCO₂, tidal volume, V_1.0%, minute volume and respiration rate were associated with the treatment; 3) ventilatory response to carbon dioxide under the conditions of 59-93% oxygen concentration was not impaired; 4) decreased serum levels of LTB₄, LTC₄ and histamine indicated possible reduction of bronchial hypersensitivity; 5) enhanced regulation of the autonomic nervous system was achieved; 6) occasions requiring aminophylline infusion therapy were reduced; 7) patients' subjective comments.
In conclusion, in terms of the parameters analyzed in the present study, repeated SGB can be recommended as an adjunctive approach to control of bronchial asthma.