Leiomyoma is the most common benign tumor of the esophagus, but its familial occurence is very rare. Only a few cases has been reported in the world. Recently, we experienced the esophageal leiomyoma occured in sisters. The elder sister's tumor was recognized at 7 year old in 1966, which was probably the youngest case of the esophageal leiomyoma in Japan. The younger sister's tumor happened to be recognized at 18 in 1981. Both tumors are bigger, circular, and located in a lower third part of the esophagus. These characters are very like those of the other reported cases, and all cases are seen in females.