抄録
Excretion of intravenously given antibiotics (LMOX and CMZ) into the bile was studied in 16 patients who had had hepatic portoenterostomy with Suruga II type enterostomy for congenital biliary atresia. Excretion of antibiotics into the bile was excellent and almost the same as that seen in adult patients in two cases of Group I (correctable type, jaundice disappeared after the operation). Excretion of antibiotics into the bile was good or poor, depending on the amount of bile flow and liver function in five cases of Group IIa (non-correctable type, jaundice disappeared after the operation). Excretion of antibiotics into the bile was very poor in five cases of Group IIb (non-correctable type, jaundice persisted after the operation). Excretion of antibiotics into the bile was good but variable depending on the amount of bile flow and liver function in four cases of Group III (non-correctable type, jaundice disappeared after the operation, the test was done in the early postoperative period). Results of the present studies indicate that biliary excretion of intravenously given antibiotics is closely related to the condition of the liver function and biliary passage in these patients.
