The influence of anesthetics on gastroesophageal intraluminal pressure was studied using twenty one mongrel dogs. Eleven dogs were anesthetized with barbiturate (Barbital group) and ten dogs with ketamine (Ketamine group). The lower esophageal sphincter (LES) pressure with pull-through method and simultaneous gastroesophageal intraluminal pressure were measured. The results are as follows; 1) LES pressure was lower in Barbital group than in Ketamine group. 2) In measurement of simultaneous gastroesophageal intraluminal pressure, esophageal peristalsis was not induced by water instillation into pharynx, balloon distension or electrical stimulation of the upper esophagus in Barbital group. On the other hand, esophageal peristalsis and LES relaxation were induced and clearly identified. 3) In manometric study, anesthetic agent such as barbiturate which inhibit bowel motility, should be avoided and experimental condition must be standardized.
