幼若ラットにおける大腸全摘及び半切後の病態に関する実験的研究

抄録

The influence of massive colectomy upon growth and development, histological changes of residual gut, and mucosal enzyme activity were investigated in juvenile Rats (4-6 weeks old). Total colectomy manifests a great influence on growth and development in juvenile Rats, presenting a remarkable reduction in growth curve particularly in male Rats. The tendencies of polyphagia and polydipsia were observed corresponding to severe diarrhea and significant decrease of serum sodium, total protein and blood sugar. In the residual gut, remarkable distension of ileum and mucosal hypertrophic change were seen in the early stage (1 month after operation), which seem to be compensatory changes. Shortness in hight and increase in number of the villi were recognized in the ileum during middle and late stages (3-6 months after operation), which seem to be characteristic in juvenile Rats. The change of mucosal enzyme activity was studied to investigate functional effect on the residual gut. The decreased of alkalinephosphatase activity in the late stage corresponding to the number of epithel cells, the compensatory increase of Na-K-ATPase activity in the early stage and its decrease in middle and late stage, coincided with the histological findings. The growth, development, blood chemical findings and mucosal enzyme activity were less influenced by hemicolectomy than by total colectomy. Regarding the histological changes upon the residual guts, right side hemicolectomy was much more influential than left side hemicolectomy.