A 7-month-old girl with Cushing's syndrome caused by left adrenocortical carcinoma and the result of determination of hormones in the supernatant of tumor cell culture were reported. The baby was admitted with the following clinical manifestation of Cushing's syndrome: general obesity, moon fade, hypertension and hypertrichosis. The urinary excretion of 17 KS and 17 OHCS and the concentration of serum cortisol were elvated almost 5 times as nomal baby. A left adrenal tumor was diagnosed by ultrasound, CT scan and angiography. Complete extirpation of the tumor was performed successfully. Pathological diagnosis was adrenocortical carcinoma. Postoperative replacement therapy with hydrocortisone and predonine was given for 330 days. Remarkable elevation of adrenocortical hormones was demonstrated in the culture supernatant of the tumor cells. The patient is healthy with no evidence of recurrence 16 months after the operation.
