Anti-neuroblastoma monoclonal antibody (CNM-5) was labeled with 131I and injected into transplantable human neuroblastoma bearing mice. Apparent inhibition of tumor growth was observed in animals thus treated as compared animals of the control group, CNM-5 alone group and 131I alone group. (p<0.05) In addition, pathohistological study revealed binding of 131I to tumor cells (Radioautography) and necrotic changes, suggesting a possibility of application of this monoclonal antibody to the treatment of neuroblastoma.
