抄録
In 40 patients with prosthetic heart valves and 3 patients who underwent open mitral commissurotomy, fibrinopeptide A (FPA) and soluble fibrin monomer complex (SFMC) were measured by enzyme immunoassay and fibrin monomer test (FM test), respectively. The relationship between these two parameters and either von Willebrand factor antigen (vWF:Ag), antithrombin III (ATIII) or thrombo-test (TTO) were analyzed.
FPA was elevated in 41.9% and FM test was positive in 25.6% of the patients. High FPA values were obtained frequently in patients with positive FM test. TTO, vWF:Ag and ATIII were not correlated with plasma concentration of FPA. FM test was not correlated with TTO or vWF:Ag, but positive results in FM test were frequently observed in potients with low plasma level of ATIII.
These results indicate that low TTO does not mean suppressed thrombin generation in vivo, and that FPA and FM test would be valuable parameters of hypercoagulability in these patients.
