抄録
The plasma levels of von Willebrand factor (vWF), protein C (PC) and antithrombin III (AT III) were examined in 32 patiens with cerebrovascular disease (CVD).
The mean vWF activity in 17 patients with cerebral infarction of acute phase was significantly higher (p<0.05) than age matched controls and in 6 patients of chronic phase was within normal limits. The mean PC antigen in 15 patients with cerebral infarction of acute phase was significantly (p<0.05) lower than 64 normal controls and in 6 patients of chronic phase was within normal limits. The mean AT III activity in 18 patients with CVD of acute phase was lower than normal controls, but was not statistically significant.
Linear correlations were found between vWF and PC (r=-0.48, p<0.01), and between PC and AT III (r=0.40, p<0.05) in 32 patients with CVD.
These results suggest that the increased level of plasma vWF in patients with CVD of acute phase may reflect endothelial damage, regeneration of the damaged endothelium and overproduction of vWF from the endothelial cells, and that decreased levels of plasma PC in patients with cerebral infarction is due to consumption at acute phase of the disease.
