肝硬変症, 肝細胞癌症例における組織プラスミノーゲンアクチベータ (t-PA) の測定と臨床的意義
1989 年 20 巻 1 号 p. 74-77
詳細
1989 年 20 巻 1 号 p. 74-77
Previous studies revealed that plasma tissue plasminogen activator (t-PA) level was elevated in patients with liver disease. In this study, the correlations between levels of plasma t-PA and serum total bilirubin (T. Bil) and hepatic synthetic functions were investigated in patients with chronic liver diseases (chronic hepatitis CH; N=8, liver cirrhosis LC; N=63) and with hepatocellular carcinoma (HCC; N=35).
The t-PA levels showed significant increase in patients with LC and HCC, especially in the decompensated stage of LC, compared with normal controls (N=20). Moreover, the t-PA levels significantly correlated positively with T. Bil levels and negatively with liver synthetic functions such as serum albumin, protein C in patients with LC.
Serial determination of t-PA levels in 8 HCC cases treated tsanscatheter arterial embolization (TAE) revealed that the values showed rapid and transient rises after TAE and returned to almost the pre-treatment levels on the 7th day after TAE. Therefor, we assume that the elevated t-PA levels in these HCC cases were due not to increased production of t-PA by hepatoma itself, but mainly to impaired liver function.
