抄録
Successful resection of a cerebellar tumor found in a patient with severe hemophilia A using RCG-11 (monoclonal purified F VIII concentrates) is reported. Pt (I. S.) is a 43-yr.-severe hemophilia A with numerous bleeding episodes but no inhibitor to F VIII. Since Jan 1991, he has been suffering from headache, vertigo, nausea and a diagnosis of cerebellar tumor was made by Computer Tomography sand Magnetic Resonance Imaging. Complete resection of cerebellar tumor was performed after infusion of RCG-11 in dose of 60U/kg and total blood loss was 210gram. Neither HIV antibody nor HBs antigen in his serum turned positive 3 months later.
Pharmacokinetic analysis of RCG-11 administered in dose of 50U/kg showed that t1/2 of RCG-11 was 12.8 hrs and in vivo recovery rate was 80%, which were similar to those of commercially available monoclonal purified F VIII concentrates. From these results, RCG-11 is safe and offers effective control of major operations in patients with severe type of hemophilia A.
