A rare case of natural killer cell (NK cell) type granular lymphocyte proliferative disorders with deficiency of multiple coagulation factors is reported. On admission, both APTT and PT were prolonged with 39% of F. II, 40% of F. V, 41% of F. VII, 161% of F. VIII, 26% of F. IX, 40% of F. X and 36% of F. X II. A good correlation between coagulation abnormalities and liver dysfunction due to leukemic infiltration was seen during the course of illness. No evidence of DIC was demonstrated. It is suggested that synthesis of multiple coagulation factors was impaired due to direct infiltration to liver of NK cell type leukemic cells.
