Plasma-fibrinogen fragments (Fgfr) and fibrin fragments (Fbfr) of non-pregnant women and pregnant women with or without severe preeclampsia were measured as a molecular marker of fibrinogenolysis and fibrinolysis, respectively, in order to clarify pathological events of severe preeclampsia.
In peripheral venous blood (PVB) of 30 healthy pregnant women, the levels (median) of Fgfr were slightly elevated and those of Fbfr were markedly elevated as pregnancy advanced. Concomitantly, a significant decrease in Fgfr/Fbfr ratios (0.8-0.6) was found as compared with those of nonpregnancy (median: 1.433). In 30 cases of late normal pregnancy, the higher levels of Fbfr (median: 880ng FE/ml in PVB, 980ngFE/ml in UVB) than Fgfr levels (median: 480ngFE/ml in PVB, 760ng FE/ml in UVB) were found not only in PVB, but also in uterine venous blood (UVB), and the Fgfr/Fbfr ratios were lower in PVB (median: 0.602p<0.05) than in UVB (median: 0.648).
