STUDY ON THE PREVENTION OF POST-TRANSFUSION NON-A, NON-B TYPE HEPATITIS BY MEANS OF THE SERUM GUANASE ACTIVITY

Abstract

Total of 102 patients who received blood transfusion for their cardiovascular surgery were the materials of this investigation.
The incidence of post-transfusion hepatitis in correlation to guanase (guanine deaminase) activity was studied.
Diagnosis of post-transfusion hepatitis was made when a patient showed elevation of s-GPT over 100 units in three weeks after surgery. The follow up periods were ranging from three to six months.
13 patients were developed post-transfusion hepatitis which accounted 12.7% of incidence. Patients were divided into two groups according to the level of guanase activity. Significantry high incidence was observed in the groups of patients who received transfusion with guanase activity over 2.6IU/L (12.7% VS 64.3%, χ²₀=18.06>χ²₀ (1, 0.001)=10.83)
The guanase activity in transfusion blood may be feasible as a parameter for the prevention of posttransfusion non-A, non-B type hepatitis.