Abstract
C-Reactive Protein (CRP) was positive in fifty-one blood donors out of four-thausand and twentyseven by screening with latex agglutination method. CRP concentrations of these positive samples were measured by laser nephelometer and the levels of IgG, IgM, C3, prealbumin and five kinds of protein called acute phase reactants were also measured by single radial immunodiffusion method. Furthermore, rheumatoid factor (RF) was tested by polystylene latex agglutination, and serum electrophoresis and blood chemical analysis were performed.
The concentration of CRP were ranged 1.0mg/dl to 21.3mg/dl and the twelve of these fifty-one showed more than 5mg/dl. Among these twelve samples, nine were abnormal values in three or more kinds of serum protein and seven showed inflammatory pattern in serum electrophoresis. The sixteen of fifty-one were RF positive, but there was no correlation with CRP concentration. GOT levels were slightly high in five of fifty-one and two of their CRP were more than 5mg/dl and the rest of three were less than 2mg/dl. In one case of fifty-one, the values of total protein and albumin were slightly low, 6.1g/dl and 3.4g/dl respectively. The CRP of this sample was 10.4mg/dl and five kinds of serum protein were abnormal and the serum electrophoresis showed inflammatory change.
From these serum investigations of CRP posivite serum, some donors though not to be quite healthy, thus, we should consider whether these donors are really healthy and the blood from these donors are good for transfusion.
