Abstract
Adoptive immunotherapy (AIT) in 8 patients with brain tumor was performed. LAK cells were induced from PBLs of the patients by incubation in the medium (TIL-media I+4% human AB serum), spplemented with 1000 unit/ml of rIL-2 (Sionogi Pharmac. Co.). In these patients, Ommaya's reservoir was inserted at the operative location, and the LAK cells were injected into this tube at one or two times per week. All patients were treated with radiation therapy at the start or before AIT. Any unfavorable effects of this therapy were not observed. A temporary reduction of tumor mass was observed in 3 patients. AIT with LAK cells may be useful as a supporting therapy in the post-operative patients. The obstruction of the injection tube is the most difficult problem to continue this therapy.
