抄録
Clinical and experimental studies on the hematological changes during and after the procedure of extracorporeal circulation, hypothermia and massive blood transfusion were made.
1) The disappearance of leucocytes and platelets occurred during the operations. The sequestration of these blood cells occurred in hypothermia, and the destruction in extracorporeal circulation.
2) Hemolysis accompanying the extracorporeal circulation did not disturb the renal function.
3) Decreased platelet counts were restored in one week postoperatively, but both erythrocyte and leucocyte counts were decreased between 5 to 14 days.
4) Experimentally, the half life of erythrocyte survival was shortened in all cases, being particularly severe in massive blood transfusions. Clinically, the normal half life was obtained in the brain cooling and massive blood transfusions. The shortened half life in the artificial heart-lung pump oxygenator did not completely explain the postoperative anemia.
5) It appeared that the extracorporeal circulation, especially brain cooling, stimulated erythropoiesis experimentally. In clinical cases of artificial heart-lung pump oxygenator, erythropoiesis was stimulated transiently followed by the period of inhibition.
6) Taking the hemodynamic changes into consideration, postoperative hydremia, rather than anemia, seemed to be responsible for the inhibition of the bone marrow function.
