抄録
The author measured circulating blood volume, extracellular fluid volume, venous hematocrit value, serum electrolytes, and plasma protein concentration before, during and after the intracardiac surgery by the pump-oxygenator (metal finger pump and DeWall-Lillehei type oxygenator), and studied the changes of circulating blood volume and venous and body hematocrit value before and during the extracorporeal circulation.
The results obtained were as follows:
1) Circulating blood volume decreased immediately after the perfusion in both experimental and clinical cases, in spite of blood transfusion in amounts greater than those of blood loss.
A part of circulating blood is presumed to be pooled in the storage depots in patients or dogs.
2) In experiments with dogs, venous hematocrit values increased during the perfusion, while body hematocrit values decreased slightly. It is believed that these changes were caused by the unbalanced distribution of red cells in the blood vessels.
In clinical cases venous hematocrit values decreased immediately after the perfusion.
3) Fxtracellular fluid volume measured by thiocyanate increased in almost all cases immediately after the perfusion in proportion to the increase of body weight.
4) Serum potassium concentration decreased during and immediately after the perfusion, but the maximum increase was noted on the 1st and 2nd postoperative days.
Serum sodium and chloride concentrations increased slightly during the perfusion and showed decreased level for about one week after the surgery. Extracellular sodium and chloride volumes increased for about two weeks postoperatively.
5) Plasma protein concentration decreased during the perfusion and for about one week after the surgery.
Consequently, it should be emphasized that the administration of saline solution or 5 percent glucose solution must be restricted during and after the intracardiac surgery.
