Abstract
There have been no guidelines regarding clinical trials of antimicrobials for canine pyoderma in Japan. A novel guideline for evaluating clinical signs is introduced by the Japanese Society of Antimicrobials for Animals to improve the objective clinical evaluation. This guideline was validated using clinical cases of canine pyoderma. There was statistically significant correlaiton in clinical scores of erythema, papule/pustule, crust, hair loss, swelling, pain and total scores between two veterinarians. Then, the conventional evaluation method and a novel guideline were compared by the veterinarian, there was also significant correlation between two evaluation methods. From these results, a novel evaluation method in the newly proposed guideline is suggested to be appropriate to apply for clinical trial of canine pyoderma, and there seems to be minimum inconsistency between a conventional and a novel clinical evaluation system.
