Abstract
Four miniature Dachshunds with juvenile onset, severe peripheral edema are described. All dogs developed edema at 3 to 5 months old at the pinnae, tail and it was observed at the muzzle, periocular area, extremities, and prepuce in some. Physical examination and blood examinations included complete blood count, and serum chemistry analysis showed no evidence suggesting a primary cause of edema in three cases. Case 4 showed temporary, moderate hypoalbuminemia, but no clinical and laboratory findings to lead underline disorders were found. Histopathologic findings revealed pale-staining collagen losing its fibrillar character with extensive edema in the dermis in all dogs. Based on these findings, congenital vascular disturbance in the skin was suspected and the edema was reduced after administration with tocopherol nicotinate and/or carbazochrome sodium sulfonate hydrate.